凝集素样氧化型低密度脂蛋白受体的病理作用和药物靶点研究

被引:3
作者
张天泰
杜冠华
机构
[1] 中国医学科学院/中国协和医科大学药物研究所,中国医学科学院/中国协和医科大学药物研究所北京,北京
关键词
氧化型低密度脂蛋白; 凝集素样氧化型低密度脂蛋白受体-1; 动脉粥样硬化;
D O I
10.13220/j.cnki.jipr.2004.04.004
中图分类号
R363 [病理生理学]; R96 [药理学];
学科分类号
100104 ; 100602 ; 100706 ;
摘要
氧化型低密度脂蛋白 (OxLDL)是动脉粥样硬化的主要致病因素 ,但是OxLDL必须通过其特异性受体 ,凝集素样氧化型低密度脂蛋白受体 1 (LOX 1 )的介导才能发挥作用。近来研究发现 ,众多因素能调控LOX 1的病理表达 ,内皮细胞吞噬与LOX 1结合OxLDL后触发一系列信息通路 ,调控转录因子的表达 ,使粘附分子、炎症因子等表达上调 ,活性氧表达降低 ,导致内皮损伤、动脉粥样硬化等疾病形成 ,LOX 1是众多事件的初始阶段 ,所以可能成为重要的药物作用靶点
引用
收藏
页码:204 / 209
页数:6
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