常压模拟高住低练对大鼠心肌低氧诱导因子1α基因表达的影响

被引：25

作者：

黄丽英

林文弢

翁锡全

机构：

[1] 广州体育学院运动人体科学系

[2] 广州体育学院运动人体科学系广州

[3] 广州

来源：

中国运动医学杂志 | 2004年 / 02期

关键词：

高住低练; 大鼠; 心肌; 低氧诱导因子1α; 基因表达;

D O I：

10.16038/j.1000-6710.2004.02.004

中图分类号：

R87 [运动医学];

学科分类号：

100216 ;

摘要：

目的 :探讨常压下不同低氧 (14 5 %、12 6 %氧含量 )模拟高住低练对低氧诱导因子 1α(HIF - 1α)mRNA表达的影响 ,为运动与低氧适应提供理论依据。方法 :采用RT -PCR技术检测大鼠心肌HIF - 1αmRNA水平。结果 :与低住安静组和低住低练组比较 ,模拟海拔 30 0 0m急性模拟高住低练组和模拟高住低练组HIF - 1αmRNA表达均显著上调 ;模拟海拔 4 0 0 0m急性模拟高住低练组HIF - 1αmRNA表达显著上调 ,模拟高住低练组则无显著性差异 ,而显著性低于急性模拟运动组。提示不同海拔低氧刺激与运动对HIF - 1αmRNA表达的影响不同 ,30 0 0m海拔比 4 0 0 0m更为适宜

引用

页码：133 / 135+141 +141

页数：4

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