结缔组织病相关肺间质病变的血清生物标志物研究进展

被引：9

作者：

殷培 ^{[1
]}

石桂秀 ^{[2
]}

机构：

[1] 四川大学华西临床医学院

[2] 厦门大学附属第一医院风湿免疫科

来源：

实用医院临床杂志 | 2014年 / 11卷 / 03期

关键词：

结缔组织病; 肺间质病变; 血清学生物标志;

D O I：

暂无

中图分类号：

R593.26 [皮肌炎];

学科分类号：

100201 [内科学];

摘要：

结缔组织病相关肺间质病变(connective tissue disease-associated interstitial lung disease,CTD-ILD)是结缔组织疾病的较为严重的并发症,诊断方式复杂,且在疾病早期阶段难以发现,预后极差,目前治疗手段有限,因此早期诊断,及早干预极为关键。CTD-ILD血清生物标志物检测简单易行,对于疾病的早期诊断及病情监测有着重要的意义。目前对血清生物标志物的研究主要集中在:基质金属蛋白酶MMPs、基质金属蛋白酶组织抑制因子TIMPs、趋化因子CCL家族和CXCL家族、IL家族、肺泡上皮蛋白、糖蛋白、骨桥蛋白、中性粒细胞弹性蛋白酶、氧化应激标志物、抗Jo-1及抗CADM-140等方面。本文就结缔组织病相关肺间质病变的血清学生物标志最新进展进行综述。

引用

页码：151 / 155

页数：5

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