利用TyG指数评估胰岛素抵抗及糖尿病的患病风险

被引：16

作者：

张文 ^{[1
]}

文重远 ^{[2
]}

解为慈 ^{[1
]}

机构：

[1] 天门市第一人民医院内分泌科

[2] 武汉大学人民医院内分泌科

来源：

海南医学 | 2019年 / 30卷 / 22期

关键词：

TyG指数; 胰岛素抵抗; 糖尿病; ROC曲线; 横断面研究;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

目的通过甘油三酯血糖指数(TyG指数)评估胰岛素抵抗及糖尿病患病风险。方法研究人群来自中国健康与营养调查(CHNS)数据库,以参加2009年调查的人群为研究样本,采用Spearman相关分析了解TyG指数与稳态模型胰岛素抵抗指数(HOMA-IR)之间的相关性,利用Logistic回归分析分析TyG指数与糖尿病的患病风险,采用ROC曲线分析TyG指数诊断胰岛素抵抗及糖尿病的效能。结果 TyG指数与HOMA-IR、体质量指数(BMI)、腰围、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清胰岛素(INS)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血尿酸(UA)、超敏反应蛋白(hs-CRP)呈正相关(P<0.05),与高密度脂蛋白胆固醇(HDL-C)呈负相关(P<0.05);校正年龄、性别、体重指数后,TyG指数第2、3、4四分位数组糖尿病的患病风险相对于TyG指数第1四分位数组分别增至1.706、3.070、9.918倍;TyG指数诊断胰岛素抵抗的曲线下面积AUC(95%CI)为0.722 (0.712～0.732),最佳切点值为3.797,敏感性为64.27%,特异性为69.20%,约登指数为0.335;TyG指数诊断糖尿病的曲线下面积AUC (95%CI)为0.774 (0.765～0.783),最佳切点值为3.839,敏感性为72.39%,特异性为69.50%,约登指数为0.418。结论 TyG指数可以评估胰岛素抵抗及糖尿病患病风险。

引用

页码：2882 / 2886

页数：5

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