溃疡性结肠炎患者血清白细胞介素1β检测

被引：16

作者：

贾百灵

侯晓华

机构：

[1] 华中科技大学同济医学院附属协和医院消化科,华中科技大学同济医学院附属协和医院消化科武汉河南省人民医院消化科郑州,武汉

来源：

郑州大学学报(医学版) | 2004年 / 02期

关键词：

溃疡性结肠炎; 白细胞介素-1β; 血清;

D O I：

10.13705/j.issn.1671-6825.2004.02.049

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

目的:探讨白细胞介素-1β(IL-1β)在溃疡性结肠炎(UC)中的作用。方法:采用ELISA法测定105例UC患者及60例正常对照血清IL-1β的含量。结果:活动性UC患者IL-1β含量((62.32±13.23)ng/L)显著高于缓解期UC患者((55.47±12.48)ng/L)和正常对照组((53.82±15.79)ng/L)(P<0.05);不同病变范围IL-1β的含量:全结肠炎组((66.77±13.39)ng/L显著高于左半结肠炎组((58.71±11.00)ng/L)和远端结肠炎+直肠炎组((57.20±11.75)ng/L)(P<0.05)。结论:UC患)者血清中IL-1β含量与病变活动、范围有关,IL-1β的变化可作为监测UC活动及疗效判定的指标之一。

引用

页码：306 / 308

页数：3

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