血小板膜糖蛋白Ⅱb/Ⅲa拮抗剂临床应用的研究进展

被引:1
作者
郭美琦
包承鑫
机构
[1] 天津市第一中心医院检验中心,中国医学科学院血液学研究所天津,,天津,
关键词
血小板膜糖蛋白; Ⅱb/Ⅲa; 拮抗剂;
D O I
暂无
中图分类号
R543 [血管疾病];
学科分类号
1002 ; 100201 ;
摘要
<正> 血小板在动脉血栓形成中起着重要的作用。血小板在受到各种刺激后引起活化,产生血小板聚集,导致血栓形成,并常成为致命的因素之一。 在血小板聚集反应中,各种刺激物,譬如ADP、凝血酶、胶原等通过血小板表面相应的受体引起血小板活化反应。最终是血小板膜糖蛋白Ⅱb/Ⅲa(GP Ⅱb/Ⅲa)上的纤维蛋白原受体暴露而引起血小板聚集。因此,阻断GPⅡb/Ⅲa上的纤维蛋白原受体与纤维蛋白原的结合已被认为是阻断血小板聚集反应,抑制血小板聚集的攸关至要的步骤。
引用
收藏
页码:35 / 38
页数:4
相关论文
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