遗传异质性药物毒副作用与HLA基因关联及分子机制研究进展

被引：8

作者：

王青 ^{[1
]}

梅虎 ^{[1
,2
]}

张亚兰 ^{[1
]}

潘显超 ^{[1
]}

谭文 ^{[1
]}

晁丽 ^{[1
]}

机构：

[1] 重庆大学生物工程学院

[2] 重庆大学生物流变科学与技术教育部重点实验室

来源：

药学学报 | 2013年 / 06期

关键词：

人类白细胞抗原; 药物毒副作用; 全基因组关联分析;

D O I：

暂无

中图分类号：

R968 [遗传药理学];

学科分类号：

100706 [药理学];

摘要：

随着高通量基因测序技术的发展,全基因组关联分析(genome-wide association study,GWAS)被越来越多地应用到遗传异质性药物毒副作用(adverse drug reactions,ADRs)研究中。越来越多的研究发现:遗传异质性ADRs与人类白细胞抗原(human leukocyte antigen,HLA)密切相关,如阿巴卡韦(abacavir)与HLA-B*5701、别嘌醇(allopurinol)与HLA-B*5801、卡马西平(carbamazepine)与HLA-B*1502等基因关联。针对上述基因关联现象,相继提出半抗原理论、危险因子理论、"P-I"理论以及最新提出的自身免疫机制。本文就遗传异质性ADRs与HLA基因关联及其机制研究的最新进展进行了详细综述。

引用

页码：799 / 808

页数：10

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