筛选机制与细胞衰老的DNA损伤假说

被引:8
作者
陈作舟
机构
[1] 浙江大学生物医学工程系!中国浙江杭州
关键词
筛选机制; 细胞衰老; DNA损伤; 凋亡;
D O I
暂无
中图分类号
Q255 [细胞的衰老与死亡];
学科分类号
071009 ; 090102 ;
摘要
生物界存在某些筛选机制 ,它将DNA损伤较小的细胞筛选出来 ,产生后代。主要有两类模式———机制 1和机制 2 ,分别以细菌和人的成纤维细胞为代表 ,那些具有筛选机制 1的细胞 (如 :细菌、生殖、癌细胞 )能无限传代 ,而体细胞则不能。这两类筛选机制背后有更深刻的原因 ,而细胞的癌变正是从机制 2退化为机制 1的过程。
引用
收藏
页码:81 / 87
页数:7
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