基质金属蛋白酶对细胞因子的调节与肺纤维化

被引：2

作者：

陈美才

黄韧

机构：

[1] 广东医学院药理教研室

[2] 广东省实验动物监测所湛江

[3] 广州

来源：

解剖学研究 | 2004年 / 02期

关键词：

肺纤维化; 基质金属蛋白酶; 胰岛素样生长因子; 转化生长因子-β; TNF-α;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

1002 ; 100201 ;

摘要：

肺纤维化是一种进行性的并最终可致死的病理过程。其病理特征是肺内间质细胞的增生,细胞外基质的大量增多,广泛的肺实质的重建。尽管此类疾病的病理机制很复杂,认识得不够深入,但大量的实验证实基质金属蛋白酶(MMPs)可通过介导胰岛素样生长因子(IGFs)、转化生长因子-β(TGF-β)和肿瘤坏死因子-α(TNF-α)的激活和释放从而在肺纤维化病变的进程中发挥重要的作用。

引用

页码：150 / 151+154 +154

页数：3

共 17 条

[1]

Growth factors in idiopathic pulmonary fibrosis: relative roles. Allen JT,Spiteri MA. Respiratory Research . 2002

[2]

Insulin-like growthfactor I is a major fibroblast mitogen produced by primarycultures of human airway epithelial cells. Cambrey AD,Kwon OJ,Gray AJ,et al. Clinical Science . 1995

[3]

Role of insulin-like growth factor binding proteins in controlling IGF actions. Clemmons DR. Molecular and Cellular Endocrinology . 1998

[4]

Expression of insulin-like growth factor binding proteins in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. Allen JT,Bloor CA,Knight RA. Am J Respir Cell Mol Biol . 1998

[5]

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor 1. Lee CG,Homer RJ,Zhu Z,et al. The Journal of Experimental Medicine . 2001

[6]

Remarkable roles of proteolysis on and beyond the cell surface. Blobel CP. Current Opinion in Cell Biology . 2000

[7]

The TNF and TNF receptor superfamilies: integrating mammalian biology. Locksley RM,Killeen N,Lenardo MJ. Cell . 2000

[8]

Growth factors in the extracellularmatrix. Taipale J,Keski Oja J. The FASEB Journal . 1997

[9]

Nelson AR,Fingleton B,Rothenberg ML,et al. Advances in Experimental Medicine and Biology . 2000

[10]

Environmental Health Perspectives[C]. 2010 the 5th International Academic Conference on Environmental and Occupational Medicine,2010

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