低氧诱导因子-1研究进展

被引:10
作者
宋海邦
瓦龙美
机构
[1] 首都医科大学组织学教研室
[2] 首都医科大学组织学教研室 北京
[3] 北京
关键词
低氧诱导因子; 低氧; 细胞类型; 磷酸化; 低氧条件; 常氧; 低氧细胞; 基因; 信号转导通路;
D O I
10.16695/j.cnki.1006-2947.2002.04.026
中图分类号
R341 [];
学科分类号
1001 ;
摘要
低氧诱导因子 1(HIF 1)是在低氧及模拟低氧条件下细胞产生的一种蛋白转录调控因子 ,由α和 β两种亚基组成 ,HIF 1α的磷酸化和非磷酸化状态作用不同。HIF 1涉及的信号转导通路复杂 ,广泛参与哺乳动物细胞低氧诱导性应答 ,在低氧诱导的基因表达调节中起着关键作用。本文就HIF 1的结构、作用、活性调节及在低氧信号转导中的作用等方面的研究进展作一综述
引用
收藏
页码:372 / 376
页数:5
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