人绒毛膜促性腺激素在辅助生殖技术中的研究进展

被引：9

作者：

马从顺

邢福祺

机构：

[1] 南方医科大学南方医院妇产科生殖医学中心

来源：

国际生殖健康/计划生育杂志 | 2011年 / 30卷 / 02期

关键词：

绒毛膜促性腺激素; 生殖技术,辅助; 卵泡期; 自身免疫;

D O I：

暂无

中图分类号：

R714.8 [];

学科分类号：

摘要：

人绒毛膜促性腺激素(hCG)由胎盘滋养细胞产生。随着尿源性纯hCG以及重组hCG的出现,其已广泛用于临床人工辅助生殖技术(ART)中。近年研究发现,hCG用于体外受精/胞浆内单精子注射(IVF/ICSI)周期前预处理可以提高胚胎质量及临床妊娠结局;hCG可在黄体中期长方案及拮抗剂方案中替代黄体生成激素(LH)或卵泡刺激素(FSH)用于晚卵泡期超促排卵;同时hCG还可能通过介导免疫机制促进胚胎着床等。hCG在ART临床中起着不可替代的作用。

引用

页码：111 / 114

页数：4

共 7 条

[1]

Supplementation with a recombinant human chorionic gonadotropin microdose leads to similar outcomes in ovarian stimulation with recombinant follicle-stimulating hormone using either a gonadotropin-releasing hormone agonist or antagonist for pituitary suppression [J].

Cavagna, Mario ;

Louzada Maldonado, Luiz Guilherme ;

de Souza Bonetti, Tatiana Carvalho ;

de Almeida Ferreira Braga, Daniela Paes ;

Iaconelli, Assumpto, Jr. ;

Borges, Edson, Jr. .

FERTILITY AND STERILITY, 2010, 94 (01) :167-172

[2]

Human chorionic gonadotropin: A hormone with immunological and angiogenic properties [J].

Tsampalas, Marie ;

Gridelet, Virginie ;

Berndt, Sarah ;

Foidart, Jean-Michel ;

Geenen, Vincent ;

d'Hauterive, Sophie Perrier .

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 85 (01) :93-98

[3]

Differences in gene expression of granulosa cells from women undergoing controlled ovarian hyperstimulation with either recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin [J].

Grondahl, Marie Louise ;

Borup, Rehannah ;

Lee, Young Bae ;

Myrhoj, Vibeke ;

Meinertz, Helle ;

Sorensen, Steen .

FERTILITY AND STERILITY, 2009, 91 (05) :1820-1830

[4]

Clinical effects of ovulation induction with recombinant follicle-stimulating hormone supplemented with recombinant luteinizing hormone or low-dose recombinant human chorionic gonadotropin in the midfollicular phase in microdose cycles in poor responders [J].

Berkkanoglu, Murat ;

Isikoglu, Mete ;

Aydin, Donay ;

Ozgur, Kemal .

FERTILITY AND STERILITY, 2007, 88 (03) :665-669

[5]

Novel biological and possible applicable roles of LH/hCG receptor.[J].Adam J. Ziecik;Monika M. Kaczmarek;Agnieszka Blitek;Anna E. Kowalczyk;Xiangdong Li;Nafis A. Rahman.Molecular and Cellular Endocrinology.2007, 1

[6]

Efficacy of low-dose human chorionic gonadotropin (hCG) in a GnRH antagonist protocol [J].