OPG/RANKL/RANK信号通路在运动与骨免疫学中的研究进展

被引：55

作者：

元宇 ^{[1
]}

郭健民 ^{[1
]}

邹军 ^{[2
]}

机构：

[1] 上海体育学院运动科学学院

[2] 上海体育学院科研处

来源：

中国骨质疏松杂志 | 2015年 / 21卷 / 08期

关键词：

运动; 骨免疫; 免疫细胞因子; 骨代谢; OPG/RANKL/RANK;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

自Arron在Nature上首次提出"骨免疫学"的概念以来,关于免疫系统与骨骼系统的研究逐渐成为国内外学者研究的热点。在骨免疫学研究中,OPG/RANKL/RANK信号通路作为免疫系统参与骨代谢调节的主要通路一直备受关注。当机体运动时,运动所产生的机械应力以及运动诱导的免疫功能变化均能通过OPG/RANKL/RANK信号通路影响骨代谢。适宜的运动能上调OPG基因表达,抑制RANKL分泌及其基因表达,促进IL-2、IL-18、IFN等保护性免疫细胞因子的分泌,有助于骨形成,使骨代谢趋向正平衡。而长时间大强度运动以及过度训练则上调RANKL基因表达,下调OPG基因表达,促使破骨细胞活性增强,同时又诱导IL-6、TNF、IL-17等炎症性细胞因子分泌增多,间接促进骨吸收,使骨代谢趋向负平衡。为了更深入地了解运动、免疫以及骨代谢之间的关系,本文综述了国内外关于运动、免疫与骨代谢的报道,旨在探讨运动对骨代谢及OPG/RANKL/RANK信号通路的调节机制以及运动应激下免疫细胞因子对OPG/RANKL/RANK信号通路的影响,为运动与骨免疫学的研究及骨代谢疾病的预防提供理论基础。

引用

页码：1005 / 1010

页数：6

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