结直肠癌发生机制研究进展

被引：17

作者：

陈慧

詹俊

机构：

[1] 中山大学孙逸仙纪念医院消化内科

来源：

胃肠病学 | 2013年 / 18卷 / 03期

关键词：

结直肠肿瘤; 分子作用机制; 治疗;

D O I：

暂无

中图分类号：

R735.3 [肠肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

结直肠癌是最常见的恶性肿瘤之一,其发生由遗传和环境等诸多因素相互作用所致,是一个涉及多基因、多阶段的复杂过程。本文就结直肠癌发生机制包括染色体不稳定(CIN)、微卫星不稳定(MSI)、CpG岛甲基化表型(CIMP)等的研究进展作一综述。

引用

页码：188 / 190

页数：3

共 8 条

[1]

Serrated polyposis syndrome: Molecular, pathological and clinical aspects [J].

Guarinos, Carla ;

Sanchez-Fortun, Cristina ;

Rodriguez-Soler, Maria ;

Alenda, Cristina ;

Paya, Artemio ;

Jover, Rodrigo .

WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (20) :2452-2461

[2]

抑癌基因APC蛋白在结直肠粘膜及结直肠癌中的表达 [J].

王东旭 ;

房殿春 ;

阎晓初 ;

刘为纹 ;

柳凤轩 .

中华病理学杂志, 1999, (06)

[3]

The molecular biology of colorectal carcinoma and its implications: A review [J].

Harrison, Sanjay ;

Benziger, Harrison .

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2011, 9 (04) :200-210

[4]

Genomic and epigenetic instability in colorectal cancer pathogenesis [J].

Grady, William M. ;

Carethers, John M. .

GASTROENTEROLOGY, 2008, 135 (04) :1079-1099

[5]

Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation [J].

Lee, Sun ;

Cho, Nam-Yun ;

Choi, Minhee ;

Yoo, Eun J. ;

Kim, Jung-Ho ;

Kang, Gyeong H. .

PATHOLOGY INTERNATIONAL, 2008, 58 (02) :104-113

[6]

Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice? [J].

Sandmeier, Dominique ;

Seelentag, Walter ;

Bouzourene, Hanifa .

VIRCHOWS ARCHIV, 2007, 450 (06) :613-618

[7]

Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps..Sandmeier D;Benhattar J;Martin P; et al;.Histopathology.2009, 02

[8]

Prognostic role of KRAS and BRAF in stage Ⅱ and Ⅲ resected colon cancer:results of the translational study on the PETACC-3; EORTC 40993; SAKK 60-00 trial..Roth AD;Tejpar S;Delorenzi M;et al;.J Clin Oncol.2010, 03

← 1 →