肝脏移植与肠道微生态变化的研究进展

被引:6
作者
陶亮
任志刚
王伟林
机构
[1] 浙江大学医学院附属第一医院肝胆胰外科
基金
国家基础研究计划;
关键词
肝脏移植; 肠道微生态; 肝脏-微生态轴;
D O I
暂无
中图分类号
R657.3 [肝及肝管];
学科分类号
100408 [卫生政策与卫生管理学];
摘要
肝移植已成为公认的治疗终末期肝疾病的有效手段。由于"肝-肠轴"和"肝脏-微生态轴"的存在,肝移植术后感染和移植肝损伤与肠道微生态变化密切相关。本研究综述了肝脏移植与肠道微生态变化的研究进展,主要包括大鼠肝移植中缺血再灌注损伤与肠道微生态变化、大鼠肝移植后移植排斥损伤与肠道微生态变化、大鼠肝损伤肝移植与肠道微生态变化的互作关系,以及临床肝移植围手术期、术前术后等与肠道微生态变化的研究。同时,指出了临床肝脏移植与肠道微生态变化可能的研究方向,提出了肝移植后微生物标志物的鉴定及潜在的靶向微生物治疗的策略。
引用
收藏
页码:1458 / 1462
页数:5
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