白三烯拮抗剂ONO-1078对小鼠局灶性脑缺血的保护作用

被引：10

作者：

曾玲晖

张纬萍

王仁定

王苹丽

魏尔清

机构：

[1] 浙江大学医学院神经生物学实验室!浙江杭州

来源：

药学学报 | 2001年 / 02期

关键词：

ONO-1078{pranlukast,4氧-8-[对(4-苯丁氧基)苯甲酰氨基]-2-(5-四唑基)-4H-1-苯并吡喃半水合物}; 地塞米松; 尼莫地平; 脑缺血; 脑梗死; 脑水肿;

D O I：

10.16438/j.0513-4870.2001.02.019

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

AIM To determine whether ONO 1078 {pranlukast, 4 oxo 8 [p (4 phenylbutyloxy) benzoyl amino] 2 (tetrazol 5 yl) 4H 1 benzopyran hemihydrate}, a potent leukotriene antagonist, has protective effect on focal cerebral ischemia in mice. METHODS Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice. ONO 1078 (0 01, 0 05, 0 10 mg·kg -1 ), dexamethasone (0 5 mg·kg -1 ), nimodipine (0 2 mg·kg -1 ) or saline (control) were injected ip once daily for 3 days, and 30 min before MCA occlusion. Twenty four hours after cerebral ischemia, the neurological scores were evaluated, infarct volumes and areas of the right and left cerebral hemispheres were measured by computer imaging analysis. RESULTS ONO 1078, dexamethasone and nimodipine reduced the neurological scores. ONO 1078 and dexamethasone reduced the ratio of right/left hemisphere area, indicating inhibition of brain edema, while nimodipine showed no effect. ONO 1078 dose dependently reduced infarct size, and dexamethasone and nimodipine showed the same effect. CONCLUSION ONO 1078 showed protective effect on focal cerebral ischemia. This may represent a novel approach to the treatment of acute cerebral ischemia.

引用

页码：148 / 150

页数：3

共 7 条

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