依达拉奉联合rt-PA治疗对脑梗死患者的抗心磷脂抗体、内皮素-1和D-二聚体的影响

被引：14

作者：

潘丹红

瞿笑丰

沈燕

机构：

[1] 上海市浦东医院神经内科

来源：

临床和实验医学杂志 | 2014年 / 13卷 / 09期

关键词：

脑梗死; 依达拉奉; 重组组织型纤溶酶原激活剂; 抗心磷脂抗体; 内皮素-1; D-二聚体;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的观察依达拉奉联合重组组织型纤溶酶原激活剂(rt-PA)治疗对脑梗死的疗效及其对机体抗心磷脂抗体(ACA)、内皮素-1(ET-1)和D-二聚体的影响。方法选择2011年1月至2013年12月住院急性脑梗死患者90例为对象,随机分为观察组和对照组,每组各45例。对照组予以rt-PA治疗,观察组在对照组的基础上予以依达拉奉治疗。观察两组的疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)和日常生活活动能力量表(ADL),ACA,ET-1和D-二聚体水平的变化。结果观察组的总有效率为93.33%明显高于对照组的75.56%,差异有统计学意义(χ2=4.145,P<0.05)。治疗后两组NIHSS评分、ET-1和D-二聚体水平较治疗前明显降低(P<0.01),观察组的降低水平更为明显(P<0.01);而两组治疗后的ADL评分均较治疗前明显升高(P<0.01),观察组的升高水平更为明显(P<0.01)。结论依达拉奉联合rt-PA治疗急性脑梗死疗效确切,可能通过调节机体的脑血管舒缩功能、减轻脑水肿,保护脑神经细胞,从而达到改善神经功能的作用。

引用

页码：702 / 705

页数：4

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