单一钙制剂与钙制剂联合维生素D干预治疗老年男性骨质疏松症疗效的随机对照临床研究

被引：28

作者：

曾勇

李庆

何睿

石化洋

机构：

[1] 成都市第二人民医院骨科

来源：

临床和实验医学杂志 | 2014年 / 13卷 / 08期

关键词：

老年人; 男性; 骨质疏松; 维生素D; 钙; 骨密度;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

目的探讨单一钙制剂和钙制剂联合维生素D(Vd)治疗老年骨质疏松的疗效。方法共纳入380例男性老年骨质疏松症患者,随机分为单纯补钙组(单一钙制剂)和联合补钙组(钙制剂+Vd),各190例,观察治疗前和治疗后个体的骨密度和骨质疏松各项指标。结果在治疗3个月后,两组老年患者中全身腰椎2～4、股骨颈和大转子部位的骨密度(BMD)均有所增加,其中Vd+钙制剂组中各BMD与干预前相比有显著性差异(P<0.05)。在6个月末两组之间BMD无显著差异,血清羟脯氨酸水平在Vd+钙组中显著降低(P<0.05)。结论补充适宜的钙和Vd对于按男性老年骨质疏松的预防有一定作用,单纯补钙不如同时补充钙和Vd对体成分和BMD的改善效果明显。补钙的同时服用Vd可以显著提升体内的Vd水平和短期内骨组织的密度,预防老年人的骨钙流失。

引用

页码：625 / 629

页数：5

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