AT1受体拮抗剂和ACEI对MI后心室重构作用的比较

被引：4

作者：

车京津

机构：

[1] 天津医科大学第二医院天津

来源：

中国心血管杂志 | 2002年 / 05期

关键词：

心肌梗死; 心室重构; 血管紧张素转换酶抑制剂; 选择性1型血管紧张素Ⅱ受体拮抗剂;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

心肌梗死 ( myocardial infarction,MI)后心室重构对 MI患者的预后具有深远的影响。 MI后循环和心脏局部组织中的肾素 -血管紧张素系统 ( renin-angiotensin system ,RAS)被激活 ,在刺激全身和心脏局部产生代偿反应的同时 ,也带来危害——心肌肥厚和间质纤维化。应用血管紧张素转换酶抑制剂 ( angiotensin converting enzyme inhibitor,ACEI)阻断这一系统 ,已显示出具有防止心脏重构、延长患者生存时间的作用。其作用主要归因于抑制循环及局部血管紧张素 ( angiotensin ,Ang )的生成 ,以及减少缓激肽 ( bradykinin,BK)的降解。与 ACEI相比 ,选择性 1型血管紧张素受体 (简称 AT1受体 )拮抗剂在理论上能够更加长期、有效地阻断血管紧张素通过其 1型受体发挥的作用 ,且其作用并不仅限于此。

引用

页码：372 / 375

页数：4

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