肌成纤维细胞在心肌梗死后重构中的作用及机制

被引：9

作者：

李秀

刘巍

机构：

[1] 哈尔滨医科大学附属第一医院心内科

来源：

国际心血管病杂志 | 2014年 / 41卷 / 02期

关键词：

成纤维细胞; 肌成纤维细胞; 心肌梗死; 重构; 纤维化;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

成纤维细胞在心肌梗死后心脏修复和重构中起着重要作用,参与其中多个环节,调节细胞外基质的代谢,具有分化为肌成纤维细胞的潜能。肌成纤维细胞比成纤维细胞的表型更丰富,能更有效地对坏死细胞及间质进行修复和重构。然而,持久的肌成纤维细胞激活则会引起病理性纤维化,导致心律失常、心肌僵硬、心力衰竭的发生。

引用

页码：88 / 90

页数：3

共 12 条

[1]

Global impact of RNA splicing on transcriptomremodeling in the heart [J].

Chen GAO Yibin WANG Molecular Biology Institute University of California Los Angeles California USA .

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2012, 13 (08) :603-608

[2]

Impact of normalization strategy on cardiac expression of pro-inflammatory cytokines: Evaluation of reference genes in different human myocardial regions after Left Ventricular Assist Device support [J].

Caselli, Chiara ;

D'Amico, Andrea ;

Caruso, Raffaele ;

Cabiati, Manuela ;

Prescimone, Tommaso ;

Cozzi, Lorena ;

Cannata, Aldo ;

Parodi, Oberdan ;

Del Ry, Silvia ;

Giannessi, Daniela .

CYTOKINE, 2013, 63 (02) :113-122

[3]

Epigenetic regulation of wound healing and fibrosis [J].

Mann, Jelena ;

Mann, Derek A. .

CURRENT OPINION IN RHEUMATOLOGY, 2013, 25 (01) :101-107

[4]

Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti‐angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ‐tocotrienol.[J].Partha Mukhopadhyay;Somak Das;Md Kaimul Ahsan;Hajime Otani;Dipak K. Das.Journal of Cellular and Molecular Medicine.2012, 10

[5]

Circulating levels of soluble Fas ligand and left ventricular remodeling after acute myocardial infarction (from the REVE-2 study).[J].Marie Fertin;Anne Bauters;Florence Pinet;Christophe Bauters.Journal of Cardiology.2012, 2

[6]

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo [J].

Davis, Jennifer ;

Burr, Adam R. ;

Davis, Gregory F. ;

Birnbaumer, Lutz ;

Molkentin, Jeffery D. .

DEVELOPMENTAL CELL, 2012, 23 (04) :705-715

[7]

Usefulness of Circulating Biomarkers for the Prediction of Left Ventricular Remodeling After Myocardial Infarction [J].

Fertin, Marie ;

Dubois, Emilie ;

Belliard, Aude ;

Amouyel, Philippe ;

Pinet, Florence ;

Bauters, Christophe .

AMERICAN JOURNAL OF CARDIOLOGY, 2012, 110 (02) :277-283

[8]

Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts [J].

Cho, J. -S. ;

Moon, Y. -M. ;

Park, I. -H. ;

Um, J. -Y. ;

Moon, J. -H. ;

Park, S. -J. ;

Lee, S. H. ;

Kang, H. J. ;

Lee, H. -M. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2012, 42 (06) :872-882

[9]

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT.[J].Asish K. Ghosh;Varun Nagpal;Joseph W. Covington;Marissa A. Michaels;Douglas E. Vaughan.Cellular Signalling.2011, 5

[10]

Investigating the role of substrate stiffness in the persistence of valvular interstitial cell activation [J].

Quinlan, Angela M. Throm ;

Billiar, Kristen L. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A (09) :2474-2482

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