中药有效成分在抗衰老与抗肿瘤作用机制中的研究进展

被引:19
作者
周若宇 [1 ,2 ]
孙曼婷 [2 ]
刘静 [2 ]
罗瑛 [1 ,2 ]
机构
[1] 昆明理工大学环境科学与工程学院
[2] 昆明理工大学医学院衰老与肿瘤分子遗传学实验室
关键词
中药; 有效成分; 抗衰老效应; 抗肿瘤活性; 细胞信号通路;
D O I
暂无
中图分类号
R285 [中药药理学];
学科分类号
100806 [中药药理学];
摘要
逐年增加的研究发现衰老与肿瘤之间存在高度关联:细胞衰老可抑制肿瘤发生;衰老细胞改变细胞微环境,促进肿瘤细胞的增殖和转移。衰老和肿瘤在其发生发展过程中享有共同的细胞信号通路,这些信号通路的失调会导致衰老和肿瘤的发生和发展。因此,可平衡调节这些通路的药物可能具有抗衰老和抗肿瘤作用。一些中药有效成分在衰老和肿瘤相关的多种信号通路和分子靶标上均有作用,且不良反应较少。因此,本文对衰老和肿瘤中交叉的细胞信号进行了回顾,并在此基础上总结了目前具有抗衰老和抗肿瘤特性的中药有效成分,以及这些成分在交叉通路中的潜在机制,旨在为中药有效成分治疗衰老和肿瘤提供新的研究策略和视野。
引用
收藏
页码:1856 / 1864
页数:9
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