脑源性神经营养因子研究进展

被引：18

作者：

吴莎

华清泉

杨琨

蔡雷

机构：

[1] 武汉大学人民医院耳鼻咽喉-头颈外科

来源：

中华临床医师杂志(电子版) | 2013年 / 7卷 / 09期

关键词：

脑源性神经营养因子; 特应性皮炎; 卵巢上皮癌; 受体; 神经元; 变态反应病; 神经组织; BDNF; TrkB;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

<正>脑源性神经营养因子(BDNF)是继神经生长因子之后第二个被发现的神经营养因子[1],是一类分子量为12.3kD的碱性蛋白质,由119个氨基酸残基构成,并含有3对二硫键,在体内以二聚体的形式存在,主要分布在中枢神经系统,其中以海马及皮层组织中含量最高,另外在外周组织如心脏、肺、肌肉中也检测到BDNF的存在。BDNF不但对多种类型神经元的发育、分化以及神经的生长和再生起着维持和促进作用,而且在神经元损

引用

页码：3988 / 3990

页数：3

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