Toxicological Assessment of Trans-resveratrol

被引：10

作者：

ZENG JianguoHU YixiuZHANG Xiangqian Natural Product Research CenterHunan Agricultural UniversityChangsha China Toxicological LaboratoryHunan Provincial Center for Disease Control and PreventionChangsha China Hunan Engineering Research Center of Botanical ExtractChangsha China ^{[1
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机构：

来源：

Chinese Herbal Medicines | 2010年 / 01期

关键词：

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

Objective To evaluate toxicity and safety of trans-resveratrol(t-RSV).Methods For assays of acute toxicity,genetic toxicity,and sub-chronic toxicity,Ames test,mice bone marrow erythrocyte micronucleus,and mice sperm abnormality were performed.Results In the acute oral toxicity tests,maximum tolerable dose(15g/kg) in male and female Kunming mice showed no toxicological signs.For 90-d feeding of t-RSV at dosage range of 167-500 mg/(kg·d) in both male and female Sprague-Dawley rats,no noticeable toxicological effects were observed.Conclusion T-RSV has no acute toxicity and no genotoxicity,no harmful effects on the human body at the tested dosage range and thus resveratrol is safe for human consumption.

引用

页码：30 / 40

页数：11

共 4 条

[1]

Hormonal and genotoxic activity of resveratrol[J] E Schmitt;L Lehmann;M Metzler;H Stopper Toxicology Letters 2002,

[2]

Resveratrol; a naturally occurring polyphenol; induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line[J] Atsuko Matsuoka;Ayumi Furuta;Masayasu Ozaki;Kiyoshi Fukuhara;Naoki Miyata Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2001,

[3]

Resveratrol: A molecule whose time has come? And gone?[J] George J. Soleas;Eleftherios P. Diamandis;David M. Goldberg Clinical Biochemistry 1997,

[4]

Resveratrol Has No Effect on Lipoprotein Profile and Does Not Prevent Peroxidation of Serum Lipids in Normal Rats[J] Julio F. Turrens;Joanna Lariccia;M. Gopal Nair Free Radical Research 1997,

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