新型弹性蛋白酶抑制剂西维来司钠临床前药理及机制研究

被引:20
作者
郑修艳
曹立莉
杜冠华
机构
[1] 中国医学科学院中国协和医科大学药物研究所
[2] 沈阳药科大学药理室
[3] 中国医学科学院中国协和医科大学药物研究所 北京
[4] 沈阳
[5] 北京
关键词
西维来司钠; 弹性蛋白酶抑制剂; 全身性炎症反应综合征; 急性肺损伤;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100706 [药理学];
摘要
西维来司钠是新近研制成功的弹性蛋白酶抑制剂,大量临床前研究资料表明其能选择性地抑制中性粒细胞释放弹性蛋白酶,抑制酶活性,保护肺微血管和上皮细胞,从丽保护肺组织,改善呼吸功能,在临床上治疗全身性炎症反应综合征及特发性纤维化等引起的急性肺损伤中显示了良好的应用前景。
引用
收藏
页码:292 / 295
页数:4
相关论文
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[2]
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EFFECT OF ONO-5046; A SPECIFIC NEUTROPHIL ELASTASE INHIBITOR; ON THE PHORBOL MYRISTATE ACETATE-INDUCED INJURY IN ISOLATED DOG LUNG[J] Hong-Gang Wang Experimental Lung Research 1999,
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[5]
Effects of a neutrophil elastase inhibitor(ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFα) and activated neutrophils in isolated perfused rabbit lungs Miyazaki Y;Inoue T;Kyi M;et al; Am J Respir Crit Care Med 1998,