内皮素受体拮抗剂对糖尿病肾病的防治作用

Multiple-dose pharmacokinetics , safety and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers. Weber C,Schmitt R,Birnboeck H,et al. Journal of Clinical Pharmacology . 1999

Renal endothelin system in diabetes comparison of angiotensin-converting enzyme inhibition and endothelin-A antagonism. Hocher B,Lun A,Priem F,et al. Journal of Cardiovascular Pharmacology .

Urinary endothelin in adolescents and young adults with insulin-dependent diabetes mellitus: relation to urinary albumin, blood pressure and other factors. Peppa-Patrikiou M,Dracopoulou M,Dacout-Vouetakis C. Metabolism . 1998

Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimiental to long-term kidney function. Forbes J M,Hewitson T D,Becker G J,et al. Kidney International . 2001

Pharmacokinetics and pharmacodynamics of SB209670, an endothelin receptor antagonist: effects on the regulation of renal vascular tone. Freed M I,Wilson D E,Thompson K A,et al. Clinical Pharmacology and Therapeutics . 1999

Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelins. Chen S,Evans T,Deng D,et al. Nephron . 2002

Molecular mechanisms of diabetic renal hypertrophy. Wolf G,Ziyadeh F N. Kidney International . 1999

Renal excretory function in conscious long evans and vasopressin deficient(Brattleboro) rats after endothelin A receptor inhibition. Girchev R,Markova P,Mikhov D,et al. Acta Physiologica et Pharmacologica Bulgarica . 1998

Longterm effects of the endothelin (A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type 1 diabetes mellitus rat model. Dhein S,Hochreuther S,Aus Dem Spring C,et al. Journal of Pharmacology and Experimental Therapeutics . 2000

Absorption, excretion,and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects. Weber C,Gasser R,Hopfgartner G. Drug Metabolism and Disposition . 1999

Multiple-dose pharmacokinetics , safety and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers. Weber C,Schmitt R,Birnboeck H,et al. Journal of Clinical Pharmacology . 1999

Renal endothelin system in diabetes comparison of angiotensin-converting enzyme inhibition and endothelin-A antagonism. Hocher B,Lun A,Priem F,et al. Journal of Cardiovascular Pharmacology .

Urinary endothelin in adolescents and young adults with insulin-dependent diabetes mellitus: relation to urinary albumin, blood pressure and other factors. Peppa-Patrikiou M,Dracopoulou M,Dacout-Vouetakis C. Metabolism . 1998

Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimiental to long-term kidney function. Forbes J M,Hewitson T D,Becker G J,et al. Kidney International . 2001

Pharmacokinetics and pharmacodynamics of SB209670, an endothelin receptor antagonist: effects on the regulation of renal vascular tone. Freed M I,Wilson D E,Thompson K A,et al. Clinical Pharmacology and Therapeutics . 1999

Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelins. Chen S,Evans T,Deng D,et al. Nephron . 2002

Molecular mechanisms of diabetic renal hypertrophy. Wolf G,Ziyadeh F N. Kidney International . 1999

Renal excretory function in conscious long evans and vasopressin deficient(Brattleboro) rats after endothelin A receptor inhibition. Girchev R,Markova P,Mikhov D,et al. Acta Physiologica et Pharmacologica Bulgarica . 1998

Longterm effects of the endothelin (A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type 1 diabetes mellitus rat model. Dhein S,Hochreuther S,Aus Dem Spring C,et al. Journal of Pharmacology and Experimental Therapeutics . 2000

Absorption, excretion,and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects. Weber C,Gasser R,Hopfgartner G. Drug Metabolism and Disposition . 1999