术前血清胆红素预测冠心病支架再狭窄价值

被引：11

作者：

朱玲军

王孝雅

项美香

王建安

机构：

[1] 杭州,浙江大学医学院附属第二医院心血管内科

来源：

中华急诊医学杂志 | 2016年 / 08期

关键词：

血清胆红素; 冠心病; 支架内再狭窄;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的探讨术前血清胆红素的水平与冠心病支架术后再狭窄的相关性。方法纳入2013-2014年入住浙江大学医学院附属第二医院行冠脉造影接受支架植入治疗, 并于术后6月到12月之间再次入院行冠脉造影复查的249例冠心病患者, 根据支架内有无再狭窄分为支架内再狭窄组和无再狭窄组, 通过比较两组患者术前血清胆红素的水平, 分析其与冠心病支架内再狭窄的关系。结果血清总胆红素(TBIL)冠心病支架内再狭窄组(9.93±3.87μmol/L)水平低于无再狭窄组(12.08±4.67)μmol/L, (P=0.000), 血清直接胆红素(DBIL)冠心病支架内再狭窄组(3.17±1.60)μmol/L水平低于无再狭窄组(3.89±1.83)μmol/L, (P=0.002), 血清间接胆红素(IBIL)冠心病支架内再狭窄组(6.76±2.82)μmol/L水平低于无再狭窄组(8.17±3.39)μmol/L, (P=0.001);差异具有统计学意义(P<0.05)。Spearman相关回归分析, 结果显示, TBIL、DBIL、IBIL与再狭窄呈负相关, (P<0.05),血清胆红素越低, 再狭窄发生率越高。结论冠心病再狭窄患者血清TBIL、DBIL、IBIL偏低, 再狭窄与血清TBIL、DBIL、IBIL相关性高。术前TBIL、DBIL、IBIL可作为冠心病支架内再狭窄的预测因素。

引用

页码：1031 / 1034

页数：4

共 10 条

[1]

Usefulness of the Neutrophil-to-Lymphocyte Ratio to Predict Bare-Metal Stent Restenosis[J] The American Journal of Cardiology 2012,

[2]

Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis.[J] Liu Yingru;Li Ping;Lu Jie;Xiong Wei;Oger Joel;Tetzlaff Wolfram;Cynader Max Journal of immunology (Baltimore; Md. : 1950) 2008,

[3]

Autoimmunity and oxidatively modified autoantigens[J] Biji T. Kurien;R. Hal Scofield Autoimmunity Reviews 2008,

[4]

Bilirubin and Biliverdin Treatment of Atherosclerotic Diseases[J] R. ?llinger;K. Yamashita;Martin Bilban;A. Erat;P. Kogler;M. Thomas;E. Csizmadia;A. Usheva;R. Margreiter;Fritz H. Bach Cell Cycle 2007,

[5]

Effect of reactive oxygen species on cholinergic receptor function[J] A Venkatesham;DR Krishna;J Vidya Sagar;P Sharath Babu Indian Journal of Pharmacology 2005,

[6]

Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury[J] Atsunori Nakao;Noriko Murase;Chien Ho;Hideyoshi Toyokawa;Timothy R. Billiar;Shinichi Kanno Circulation 2005,

[7]

The levels of bilirubin may be related to an inflammatory condition in patients with coronary heart disease.[J] Greabu M;Olinescu R;Kummerow F A;Crocnan D O Acta poloniae pharmaceutica 2001,

[8]

Association of serum bilirubin concentration with risk of coronary artery disease.[J] Mayer M Clinical chemistry 2000,

[9]

Uric acid; a natural scavenger of peroxynitrite; in experimental allergic encephalomyelitis and multiple sclerosis.[J] Hooper D C;Spitsin S;Kean R B;Champion J M;Dickson G M;Chaudhry I;Koprowski H Proceedings of the National Academy of Sciences of the United States of America 1998,

[10]

Bilirubin is an Antioxidant of Possible Physiological Importance[J] Stocker Roland;Yamamoto Yorihiro;McDonagh Antony F.;Glazer Alexander N.;Ames Bruce N. Science 1987,

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