植物药抑制泌尿系结石形成的化学基础

被引：5

作者：

邓芳 ^{[1
]}

罗旭彪 ^{[1
]}

陈德志 ^{[1
]}

颜流水 ^{[1
]}

欧阳健明 ^{[2
]}

机构：

[1] 南昌航空大学环境与化学工程学院

[2] 暨南大学生物矿化与结石病防治研究所

来源：

化学研究 | 2007年 / 03期

关键词：

植物药; 泌尿系结石; 体外模拟实验; 动物实验;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

植物药治疗泌尿系结石具有独特的疗效.本文综述了国内外植物药(泽泻,Phyllanthus niruri,Zeamays,Agropyron repens和Herniaria hirsute等)在体外模拟实验和动物实验中对泌尿系结石形成的影响,植物药抑制泌尿系结石形成的机制和化学基础是:植物药与钙离子发生配位,降低尿石盐的过饱和度;抑制一水草酸钙生长,诱导二水草酸钙形成;抑制晶体生长和聚集;可以保护尿路粘膜,防止晶体在肾上皮细胞上发生粘附;改变尿石形成促进剂和抑制剂的排泄量.

引用

页码：99 / 103

页数：5

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