四川省吸毒人群艾滋病病毒和梅毒新发感染的队列研究

被引：50

作者：

尹潞 ^{[1
]}

秦光明 ^{[2
]}

阮玉华 ^{[1
]}

张莉 ^{[1
]}

郝沁宁 ^{[3
]}

陈显煌 ^{[3
]}

姜正清 ^{[3
]}

宋本莉 ^{[3
]}

刘石柱 ^{[1
]}

曹晓蕴 ^{[1
]}

郝春 ^{[1
]}

陈康林 ^{[3
]}

邵一鸣 ^{[1
]}

机构：

[1] 中国疾病预防控制中心性病艾滋病预防控制中心传染病预防控制国家重点实验室

[2] 四川省疾病预防控制中心

[3] 四川省凉山州西昌市皮肤病性病防治站

来源：

中华流行病学杂志 | 2006年 / 04期

关键词：

艾滋病病毒; 梅毒; 静脉吸毒人群; 前瞻性队列研究;

D O I：

暂无

中图分类号：

R512.91 [获得性免疫缺陷综合征（AIDS艾滋病）]; R759.1 [梅毒];

学科分类号：

100401 ; 100206 ;

摘要：

目的调查四川省某地区静脉吸毒人群艾滋病病毒(HIV)和梅毒血清抗体阳转情况及其危险因素。方法 2002年11月在四川省西昌市以社区为基础招募HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,在队列每6个月随访时调查静脉吸毒人群高危吸毒行为和性行为情况, 并采集血样进行HIV和梅毒抗体检测。结果队列随访2年,静脉吸毒人群队列保持率和HIV血清抗体阳转率分别为75．7％和2．53／100人年(95％CI:1．10-3．97),在多因素Poisson回归模型分析中,民族(RR=12．42,95％CI:2．72-56．74,P=0．0012)、近3个月共用针头或注射器(RR=4．06, 95％CI:1．29-12．81,P=0．0168)与HIV血清抗体阳转的关系有统计学意义。该研究队列梅毒血清抗体阳转率为4．71/100人年(95％CI:2．59-6．82),在多因素Poisson回归模型中,女性(RR= 4．42,95％CI:1．78-10．99,P=0．0014)与梅毒血清抗体阳转的关系有统计学意义。结论该地区静脉吸毒人群HIV和梅毒新发感染率高,应采取有效的干预措施以控制HIV的传播流行。

引用

页码：293 / 297

页数：5

共 11 条

[1]

Changes in HIV-1 incidence in heroin users in Guangxi province, China. Lai S,Liu W,Chen J,et al. JAIDS Journal of Acquired Immune Deficiency Syndromes . 2001

[2]

HIV incidence among repeat HIV testers at a county hospital, San Francisco, California,USA. Kellogg TA,McFarland W,Perllman JL,et al. JAIDS Journal of Acquired Immune Deficiency Syndromes . 2001

[3]

Community-based survey of HIV transmission modes among intravenous drug users in Sichuan, China. Ruan YH,Chen KL,Hong KX,et al. Sexually Transmitted Diseases . 2004

[4] AIDS [J].

2001, American Chemical Society (79)

[5]

Rapid transmission of hepatitis C virus among young injecting heroin users in Southern China. Garten RJ,Lai S,Zhang J,et al. International Journal of Epidemiology . 2004

[6]

Risk behavior and HIV seroincidence among out-of-treatment injection drug users: a four-year prospective study. Wiebel WW,Jimenez A,Johnson W,et al. JAIDS Journal of Acquired Immune Deficiency Syndromes . 1996

[7]

Temporal trends in the incidence of human immunodeficiency virus infection and risk behavior among injection drug users in Baltimore, Maryland, 1988-1998. Nelson KE,Galai N,Safaeian M,et al. American Journal of Epidemiology . 2002

[8]

Syphilis in injecting drug users: clues for high-risk sexual behaviour in female IDUs. Muga R,Roca J,Tor J,et al. International Journal of STD and AIDS . 1997

[9]

HIV and infections of similar transmission patterns in a drug injectors’ community of Santos, Brazil. de Carvalho HB,Mesquita F,Massad E,et al. JAIDS Journal of Acquired Immune Deficiency Syndromes . 1996

[10]

HIV incidence and factors contributed to retention in a 12-month follow-up study of injection drug users in Sichuan province, China. Ruan YH,Qin GM,Liu SZ,et al. JAIDS Journal of Acquired Immune Deficiency Syndromes . 2005

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