B细胞激活因子与过敏性紫癜相关性研究

被引:8
作者
侯佳宜
机构
[1] 山西省中医院检验科
关键词
过敏性紫癜; B细胞激活因子; 免疫球蛋白;
D O I
暂无
中图分类号
R392.8 [变态反应及过敏性反应];
学科分类号
摘要
目的:通过分析B细胞激活因子(BAFF)与患者免疫球蛋白在不同类型过敏性紫癜(HSP)中的表达,初步探讨BAFF在过敏性紫癜免疫发病机制中的作用。方法:收集HSP活动期患者,包括皮肤型30例、关节型30例、腹型32例、肾型31例、混合型41例,将健康人40例作为对照组。速率散射比浊法测定免疫球蛋白水平;ELISA方法检测BAFF蛋白含量。结果:IgA仅在混合型HSP中增高,IgG和IgM在各组中并无增高;不同类型HSP活动期患者血清中BAFF表达水平均明显高于对照组;混合型HSP患者血清中BAFF表达水平与同型患者IgA表达水平呈中等程度的相关性。结论:BAFF与HSP发病时的体液免疫增强有关。
引用
收藏
页码:752 / 754
页数:3
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