乳腺癌治疗新药Herceptin

被引:14
作者
宋丽华
宋现让
机构
[1] 山东省肿瘤防治研究院
[2] 山东省肿瘤防治研究院 山东济南
[3] 山东济南
关键词
乳腺癌; Herceptin; 人表皮生长因子受体2;
D O I
暂无
中图分类号
R979.1 [抗肿瘤、抗癌药物];
学科分类号
1007 ;
摘要
Herceptin(何塞亭 )是一种针对癌基因的单抗类抗肿瘤药 ,由罗氏制药公司研制。大量的研究表明 ,Herceptin对于 HER2阳性的乳腺癌转移患者具有较好的疗效 ,可单独应用 ,也可与其它化疗药物联合应用。Herceptin的毒副作用轻 ,患者耐受良好 ,易处理 ,是一种有前途的抗肿瘤新药。
引用
收藏
页码:39 / 43
页数:5
相关论文
共 7 条
[1]  
Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Pietras RJ,Pegram MD,Finn RS,et al. Oncegene . 1998
[2]  
The concordance between the clinical trials assay (CTA) and fluorescence in situ hybridization ( FISH) in the Herceptin pivotal trials. Mass RD,Sanders C,Charlene K,et al. Proceedings of the American Society of Clinical Oncology . 2000
[3]  
Inhibitory effects of combinations of HER-2 neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Pegram M,Hsu S,Lewis G,et al. Oncegene . 1999
[4]  
Multinational study of the efficacy and safety of humanized anti -HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Cobleigh MA,Vogel CL,Tripathy D,et al. Journal of Clinical Oncology . 1999
[5]  
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti -p185HER2 neu monoclonal antibody plus cisplatin in patients with HER2 neu-over expressing metastatic breast cancer refractory to chemotherapy treatment. Pegram MD,Lipton A,Hayes DF,et al. Journal of Clinical Oncology . 1998
[6]  
Overall survival( OS ) advantage to Herceptin ( H) in HER2-overexpressing( HER2 +) metastatic breast cancer ( MBC). Norton L,Slamon D,Leyland Jones B,et al. Proceedings of the American Society of Clinical Oncology . 1999
[7]  
Recombinant humanized anti -HER2 antibody (Herceptina) enhances the antitumor activity of paclitaxel and doxorubicin against HER2 neu overexpressing human breast cancer xenografts. Baselga J,Norton L,Albanell J,et al. Cancer Research . 1998