人体5-吡咯啉羧酸还原酶在组织发育及肿瘤发生过程中的作用

被引：4

作者：

张超

孟照辉

机构：

[1] 昆明医科大学第一附属医院心内科分子心血管病研究室

来源：

临床医学 | 2016年 / 36卷 / 09期

关键词：

5-吡咯啉羧酸还原酶; 代谢; 器官发育; 肿瘤生长;

D O I：

暂无

中图分类号：

R730.231 [肿瘤病因学、发生学];

学科分类号：

摘要：

5-吡咯啉羧酸还原酶(P5CRs)是广泛存在于从原核细胞到真核细胞中的管家蛋白,位于细胞质和线粒体中,以NAD(P)H为辅酶,将谷氨酸、鸟氨酸合成的5-吡咯啉羧酸(P5C)还原为脯氨酸并生成NAD(P)+,同时,P5CRs-脯氨酸代谢循环反应与机体组织三羧酸循环(TCA)、尿素循环、以及磷酸戊糖途径密切相关,在细胞增殖、凋亡,皮肤、骨骼、脑等组织发育及口腔、头颈、淋巴瘤等肿瘤的发生发展过程中发挥着调节的作用。通过了解P5CRs的相互作用网络及多重的生物学功能,为进一步了解组织器官发育及肿瘤的发生机理提供新的理论基础。

引用

页码：122 / 124

页数：3

共 11 条

[1] Mutations in PYCR2 , encoding pyrroline-5-carboxylate reductase 2, cause microcephaly and hypomyelination[J] . Tojo Nakayama,Almundher Al-Maawali,Malak El-Quessny,Anna Rajab,Samir Khalil,Joan M. Stoler,Wen-Hann Tan,Ramzi Nasir,Klaus Schmitz-Abe,R. Sean Hill,Jennifer N. Partlow,Muna Al-Saffar,Sarah Servattalab,Christopher M. LaCoursiere,Dimira E. Tambunan,Michael E. Coulter,Princess C. Elhosary,Grzegorz Gorski,A. James Barkovich,Kyriacos Markianos,Annapurna Poduri,Ganeshwaran H. Mochida.The Ameri
[2] Proline metabolism and cancer: emerging links to glutamine and collagen[J] . James M. Phang,Wei Liu,Chad N. Hancock,Joseph W. Fischer.Current Opinion in Clinical Nutrition and Metabolic Care . 2015 (1)
[3] Bridging epigenetics and metabolism[J] . James M. Phang,Wei Liu,Chad Hancock.Epigenetics . 2013 (3)
[4] Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
Liu, Wei
Le, Anne
Hancock, Chad
Lane, Andrew N.
Dang, Chi V.
Fan, Teresa W. -M.
Phang, James M.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (23) : 8983 - 8988
[5] Proline metabolism in health and disease
Hu, Chien-an A.
Phang, James M.
Valle, David
[J]. AMINO ACIDS, 2008, 35 (04) : 651 - 652
[6] The Metabolism of Proline as Microenvironmental Stress Substrate1-3[J] . Phang,James M,Pandhare,Jui,Liu,Yongmin.The Journal of Nutrition . 2008 (10)
[7] Glutamine Metabolism and Function in Relation to Proline Synthesis and the Safety of Glutamine and Proline Supplementation1-3[J] . Watford,Malcolm.The Journal of Nutrition . 2008 (10)
[8] Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase[J] . Zhaohui Meng,Zhiyong Lou,Zhe Liu,Dong Hui,Mark Bartlam,Zihe Rao.Protein Expression and Purification . 2006 (1)
[9] Mitochondria, Oxidants, and Aging[J] . Robert S. Balaban,Shino Nemoto,Toren Finkel.Cell . 2005 (4)
[10] Oxidation of L-thiazolidine-4-carboxylate by Δ1-pyrroline-5-carboxylate reductase in Escherichia coli
Deutch, CE
Klarstrom, JL
Link, CL
Ricciardi, DL
[J]. CURRENT MICROBIOLOGY, 2001, 42 (06) : 442 - 446

← 1 2 →