中药活性成分降尿酸作用机制研究进展

被引：49

作者：

周洁

孙超

李飞

机构：

[1] 湖北医药学院药学院

来源：

中国药理学通报 | 2018年 / 34卷 / 01期

关键词：

中药; 黄酮; 皂苷; 生物碱; 高尿酸血症; 黄嘌呤氧化酶; 尿酸转运蛋白;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

高尿酸血症是由嘌呤类物质代谢紊乱和(或)尿酸排泄减少引起血尿酸增高的一组异质性疾病。中药治疗高尿酸血症的研究逐步受到关注,并取得明显进展。近年来大量实验研究表明,黄酮、皂苷、生物碱等多种中药活性成分通过抑制腺苷脱氨酶和(或)黄嘌呤氧化酶的活性减少尿酸生成,或通过调控尿酸转运蛋白的表达增加尿酸排泄,从而发挥降尿酸的药理作用。该文以高尿酸血症的发病机制为基础,对中药活性成分降尿酸的作用机制研究进行总结,综述近年的研究报道。

引用

页码：19 / 22

页数：4

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