十二指肠胃反流和幽门螺杆菌感染关系研究

被引:19
作者
陈尼维
陈维雄
朱金水
王如华
达炜
姜琳
蒋西华
机构
[1] 上海市第六人民医院消化科
关键词
十二指肠胃反流; 幽门螺杆菌; 消化性溃疡;
D O I
暂无
中图分类号
R573 [胃疾病];
学科分类号
1002 ; 100201 ;
摘要
目的 探讨消化性溃疡患者中的十二指肠胃反流对幽门螺杆菌 (Hp)感染的影响。方法  70例消化性溃疡患者 ,用核素99MTC EHIDA测定十二指肠胃反流 ,胃黏膜Giemsa染色后检测Hp和双抗体夹心ELISA法测定血清Hp IgG水平。 结果 在 42例十二指肠胃反流阴性组中 ,Hp感染率为 83.3% (35 / 42 ) ;2 8例十二指肠胃反流阳性组中 ,Hp感染率为 39.3% (11/ 2 8) ,两组间Hp感染率差异有显著性 (P <0 .0 5 )。而Hp阳性组 46例患者中 ,十二指肠胃反流阳性率为 30 .4% (14/ 46 ) ;Hp阴性组 2 4例中 ,十二指肠胃反流率为 5 8.3% (14/ 2 4) ,两组间十二指肠胃反流率差异也有显著性 (P<0 .0 5 )。结论 在消化性溃疡中 ,十二指肠胃反流对胃内Hp感染可能有抑制作用。
引用
收藏
页码:32 / 34
页数:3
相关论文
共 10 条
[1]  
Pyloric reflux and G-cell hyperfunction. Calam J,Tracy HJ. The Lancet . 1980
[2]  
Helicobacter pylori negative duodenal ulcer. Borody TJ,George LL,Brandl S,et al. The American journal of Gastroenterology . 1991
[3]  
Bile reflux and intestinal metaplasia in gastric mucosa. Sobala GM,O’Connor HJ,Dewar EP,et al. Journal of Clinical Pathology . 1993
[4]  
Prevalence of Helicobacter pylori infection in 190 control subjects and in 236 patients with gastroesophageal reflux, erosive esophagitis or Barrett’s esophagus. Csende S A,Smok G,Cerda G,et al. Diseases of the Esophagus . 1997
[5]  
Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Blaser MJ. Gastroenterology . 1992
[6]  
Increased reflux of bile into the stomach in patients with gastric ulcer. Rhodes J,Bernardo DE,Philips SF,et al. Gastroenterology . 1997
[7]  
The effect of bile acids on growth and adherence of Helicobacter pylori. Mathai E,Arora A,Cafferkey M,et al. Alimentary Pharmacology and Therapeutics . 1991
[8]  
Campylobacter pylori and duodenogastric reflux in peptic ulcer disease and gastritis. Karttunen T,Niemela S. The Lancet . 1988
[9]  
Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Morris A,Nicholson G,Bechi P,et al. The American journal of Gastroenterology . 1987
[10]  
Helicobacter pylori may induce bile reflux: link between H.pylori and bile induced injury to gastric epithelium. Ladas SD,Katsogridakis J,Malamou H,et al. Gut . 1996