急性冠状动脉综合征患者血清sCD40L升高的临床价值

被引：2

作者：

李永旺

李传伟

曲鹏

机构：

[1] 大连市中心医院心内二科

[2] 泰山医学院

[3] 大连医科大学附属二院心内科辽宁大连

[4] 山东泰安

[5] 辽宁大连

来源：

中国心血管杂志 | 2005年 / 04期

关键词：

sCD40L; 急性冠脉综合征; 白细胞介素;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的观察冠心病不同类型患者中可溶性CD40L(sCD40L)水平的变化及其与白细胞介素-6(IL-6)和白细胞介素-1β(IL-1β)之间的关系,进一步探讨急性冠状动脉综合征(ACS)临床识别和预测的炎症指标。方法采用酶联免疫吸附法测定血清可溶性CD40L浓度,采用放免方法测定IL-6和IL-1β浓度。结果急性心肌梗死(AMI)患者sCD40L水平[(4.923±3.41)ng/ml]和不稳定型心绞痛(UAP)患者sCD40L水平[(5.387±3.04)ng/ml]显著高于稳定型心绞痛(SAP)[(2.856±2.34)ng/ml,P<0.05]和对照组患者[(2.221±2.42)ng/ml,P<0.01]。ACS患者sCD40水平与IL-6呈正相关(r=0.49,P=0.008),与IL-1β无相关性(r=0.258,P=0.183),而SAP和对照组患者sCD40L与IL-6、IL-1β无相关性。同时ACS患者sCD40L水平与低密度脂蛋白有显著相关性(r=0.471,P=0.011)。结论ACS患者血清sCD40L与IL-6、IL-1β水平升高,提示其可能与ACS发生有关,是动脉粥样硬化和斑块不稳定的标志。

引用

页码：281 / 284

页数：4

共 9 条

[1]

Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy. Anne GS,Sanne van W,Thor U,et al. Journal of the American College of Cardiology . 2003

[2]

Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets. Garlichs CD,Eskafi S,Razz D,et al. Heart . 2001

[3]

Acute Tcell activation is detectable in unstable angina. Neri Serneri GG,Prisco D,Martini F,et al. Circulation . 1997

[4]

Atherosclerosis-an inflammatory disease. Ross R. The New England Journal of Medicine . 1999

[5]

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. March F,Schonbeck U,Sukhova GK,et al. Proceedings of the National Academy of Sciences of the United States of America . 1997

[6]

Increasing levels of interleukin-1R and IL-6 during the first 2days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Iasuucci LM,Liuzzo G,Fantuzzi G,et al. Circulation . 1999

[7]

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Rider PM,Rifai N,Stampfer MJ,et al. Circulation . 2000

[8]

Elevated levels of ihterleukin-6 in unstable angina. Biasucci LM,Vitelli A,Liuzzo G,et al. Circulation . 1996

[9]

Immune mechanism in atherosclerosis arteroscler. Goran K,Hansson. Arteriosclerosis Thrombosis and Vascular Biology . 2001

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