钙调神经磷酸酶-活化T细胞核因子与系统性红斑狼疮

被引：1

作者：

张群燕

蔡辉

机构：

[1] 南京军区南京总医院

来源：

国际免疫学杂志 | 2012年 / 02期

关键词：

钙调神经磷酸酶-活化T细胞核因子; 系统性红斑狼疮;

D O I：

暂无

中图分类号：

R593.241 [];

学科分类号：

摘要：

系统性红斑狼疮是一种以多种自身抗体产生为特点的侵犯多系统多脏器的自身免疫性疾病,其发病机制尚未明确,目前认为T淋巴细胞异常是SLE的发病的关键。钙调神经磷酸酶-活化T细胞核因子信号通路作为T细胞内重要的生物信号转导通路,在T细胞活化中起到调节枢纽的作用,了解CaN/NFAT信号途径在SLE中的作用及目前相关主要治疗药物的研究现状可为SLE的基础研究及临床治疗提供依据。

引用

共 11 条

[1]

Nifedipine suppresses Th1/Th2 cytokine production and increased apoptosis of anti-CD3+anti-CD28-activated mononuclear cells from patients with systemic lupus erythematosus via calcineurin pathway [J].

Lu, Ming-Chi ;

Lai, Ning-Sheng ;

Yu, Hui-Chun ;

Hsieh, Song-Chou ;

Tung, Chien-Hsueh ;

Yu, Chia-Li .

CLINICAL IMMUNOLOGY, 2008, 129 (03) :462-470

[2]

The calcineurin/NFAT signaling pathway - A novel therapeutic target in leukemia and solid tumors [J].

Medyouf, Hind ;

Ghysdael, Jacques .

CELL CYCLE, 2008, 7 (03) :297-303

[3]

Signalling to transcription:: Store-operated Ca2+ entry and NFAT activation in lymphocytes [J].

Gwack, Yousang ;

Feske, Stefan ;

Srikanth, Sonal ;

Hogan, Patrick G. ;

Rao, Anjana .

CELL CALCIUM, 2007, 42 (02) :145-156

[4]

Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction [J].

Li, Huiming ;

Zhang, Lan ;

Rao, Anjana ;

Harrison, Stephen C. ;

Hogan, Patrick G. .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 369 (05) :1296-1306

[5]

Prospective study of low-dose cyclosporine A in patients with refractory lupus nephritis.[J].Hiroe Ogawa;Hideto Kameda;Hayato Nagasawa;Naoya Sekiguchi;Hirofumi Takei;Kensei Tsuzaka;Koichi Amano;Tsutomu Takeuchi.Modern Rheumatology.2007, 2

[6]

The calcineurin phosphatase complex modulates immunogenic B cell responses [J].

Winslow, MM ;

Gallo, EM ;

Neilson, JR ;

Crabtree, GR .

IMMUNITY, 2006, 24 (02) :141-152

[7]

Characterization of binding activity between nuclear factor of activated T cells and calcineurin by amplified luminescent proximity homogeneous assay.[J].Noriko Kitamura;Osamu Kaminuma;Fujiko Kitamura;Shoichiro Miyatake.Journal of Immunological Methods.2006, 1

[8]

Molecular mechanisms involved in the estrogen-dependent regulation of calcineurin in systemic lupus erythematosus T cells [J].