槲皮素对兔骨关节炎模型关节液中IL-1β、TNFα水平的影响

被引：10

作者：

刘俊

胡军祖

陈蕾

孙岩

樊颜伟

机构：

[1] 桂林医学院第二附属医院骨科

来源：

华夏医学 | 2016年 / 29卷 / 04期

关键词：

骨关节炎; 槲皮素; 塞来昔布;

D O I：

10.19296/j.cnki.1008-2409.2016-04-002

中图分类号：

R285.5 [中药实验药理]; R-332 [医用实验动物学];

学科分类号：

100402 [劳动卫生与环境卫生学]; 100806 [中药药理学];

摘要：

目的:观察中药槲皮素对骨关节炎动物模型关节液中细胞因子IL-1β、TNFα水平的影响。方法:按照hulth法建立兔膝关节骨关节炎模型,20只实验动物随机等分成4组:1槲皮素组。2塞来昔布组。3生理盐水组。4模型组。各治疗组分别给予药物治疗4周,然后抽取关节液,ELISA法检测关节液中IL-1β、TNFα的含量。结果:槲皮素组、塞来昔布组关节液中IL-1β、TNFα水平均显著低于模型组(P<0.01)。结论:槲皮素、塞来昔布能够抑制OA模型关节滑液中IL-1β、TNFα的水平。

引用

页码：5 / 8

页数：4

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