远志皂苷对β-淀粉样肽和鹅膏蕈氨酸引起胆碱能系统功能降低的影响

被引：51

作者：

陈勤

曹炎贵

张传惠

机构：

[1] 安徽大学生命科学学院天然药物研究所,安徽大学生命科学学院天然药物研究所,安徽大学生命科学学院天然药物研究所安徽合肥,安徽合肥,安徽合肥

来源：

药学学报 | 2002年 / 12期

关键词：

远志皂苷; β-淀粉样肽; 拟痴呆模型; 学习记忆; 胆碱乙酰转移酶; 乙酰胆碱酯酶; M受体密度;

D O I：

10.16438/j.0513-4870.2002.12.001

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的　观察远志皂苷对拟痴呆模型大鼠胆碱能系统功能的作用。方法　在大鼠脑内右侧基底核内联合注射 β 淀粉样肽 1～ 40片段 (β AP1～ 40 )和鹅膏蕈氨酸建立大鼠拟痴呆模型 ,用避暗法测定模型动物的学习记忆能力 ,用放射配体结合分析法测定胆碱乙酰转移酶活性和M受体密度 ,用改良Ellman法测定脑组织乙酰胆碱酯酶活性。结果　给模型大鼠连续ig远志皂苷 6 0d后 ,远志皂苷能明显提高拟痴呆大鼠的学习记忆能力 ,显著升高脑内M受体密度和增强胆碱乙酰转移酶活性 ,能有效地抑制脑胆碱酯酶活性。结论　远志皂苷对老年性痴呆的胆碱能系统功能减退有一定的改善和治疗作用。

引用

页码：913 / 917

页数：5

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