溶酶体酶参与脑缺血性神经元死亡的分子机制(英文)

被引：65

作者：

秦爱萍

张慧灵

秦正红

机构：

[1] 苏州大学医学院药理教研室衰老与神经疾病研究室

来源：

Neuroscience Bulletin | 2008年 / 02期

关键词：

溶酶体; 组织蛋白酶; 坏死; 凋亡; 自噬; 脑缺血;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

100204 [神经病学];

摘要：

细胞死亡有凋亡(Ⅰ型)、自噬性细胞死亡(Ⅱ型)和坏死(Ⅲ型)三种方式。缺血性神经元的死亡影响着中风的发展进程。溶酶体是一种重要的细胞器,通过在酸性环境中降解不需要的胞外和胞内物质来维持细胞代谢的稳态。溶酶体酶包括组织蛋白酶和脂质水解酶,当溶酶体膜破裂时它们会被释放到细胞浆,会对细胞内环境产生危害,最终导致细胞结构的破坏。由于溶酶体含有催化蛋白、碳水化合物和脂质的酶,因此它们参与细胞的死亡看起来是情理之中的事情。本综述讨论了缺血性神经元死亡的最新进展,指出在缺血性脑损伤中溶酶体酶参与三种细胞死亡方式的可能的分子机制,同时指出了选择性的组织蛋白酶抑制剂可能是治疗中风和促进康复新的治疗靶点。

引用

页码：117 / 123

页数：7

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