甲状旁腺激素治疗骨质疏松症的研究进展

被引：14

作者：

张艺璇

李金源

机构：

[1] 华北理工大学口腔医学院

来源：

世界最新医学信息文摘 | 2018年 / 18卷 / 51期

关键词：

甲状旁腺激素; 骨质疏松症; 骨代谢;

D O I：

10.19613/j.cnki.1671-3141.2018.51.032

中图分类号：

R580 [];

学科分类号：

摘要：

骨质疏松症(osteoporosis,OP)是一种以骨量减少,骨组织微结构系统性损伤为特点的全身性骨骼疾病,目前临床上对OP的治疗,主要通过抑制骨吸收和促进骨形成来提高骨密度,目前应用的治疗骨质疏松症的药物中,甲状旁腺激素(PTH)在维持骨稳态的过程中具有独特的双重调节作用,一方面可增加成骨细胞的数量,促进骨生长因子释放,从而促进骨形成,增加骨量,另一方面也可增强破骨细胞活性,促进骨吸收,使骨钙释放入血,因此,PTH成为骨代谢与治疗骨质疏松症相关研究的热点之一。本文简要介绍了PTH对骨代谢的调节机制,以及在实验动物和临床研究中的作用。

引用

页码：69 / 70+81 +81

页数：3

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