高血压患者血浆BNP水平与左心功能不全的关系

被引：8

作者：

夏瑾玮

邵淮鲁

王蓓云

陆懿

金俊

机构：

[1] 上海交通大学附属第六人民医院老年科

[2] 上海交通大学附属第六人民医院老年科上海市

[3] 上海市

来源：

实用老年医学 | 2005年 / 02期

关键词：

高血压; 心室功能障碍,左; 利钠肽,脑;

D O I：

暂无

中图分类号：

R544.1 [高血压]; R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨正常人群、原发性高血压及伴左室功能不全的患者脑钠素(BNP)的血浆浓度及其关系,为BNP诊断高血压心脏病(左室肥厚)提供理论依据。方法应用免疫放射法测定血浆BNP水平。选择住院原发性高血压Ⅰ～Ⅲ期患者72例,按照美国纽约心脏病协会(NYHA)心功能分级分为2组,NYHAⅠ～Ⅱ级35例,NYHAⅢ～Ⅳ级37例,以左室射血分数(LVEF)≤45%作为心功能不全诊断的标准。并以30例健康人作对照比较。结果原发性高血压组和原发性高血压伴左室肥厚组的血浆BNP平均水平均显著高于对照组(P<0.01)。结论血浆BNP是判断原发性高血压患者预后和进行危险分层的敏感指标,不仅与脉压、左室质量指数、左室舒张功能等密切相关,而且对判断左心功能不全的程度及预后都有一定的意义。

引用

页码：82 / 84

页数：3

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