VEGF相关信号通路在血管新生中的研究进展

被引：91

作者：

向本旭 ^{[1
]}

刘婷婷 ^{[1
]}

孙芳玲 ^{[1
]}

艾厚喜 ^{[1
]}

王文 ^{[1
,2
]}

机构：

[1] 首都医科大学宣武医院

[2] 北京市脑重大疾病研究院

来源：

中国比较医学杂志 | 2015年 / 25卷 / 12期

关键词：

VEGF; 血管新生; 研究进展;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

摘要：

组织器官在生理或病理状态下,受到促血管生成因子的刺激,引发生血管新生。VEGF、Notch、Wnt/β-catenin、Ang1(2)/tie2、PI3K-AKT等多个信号通路参与到该过程,对血管新生的各个阶段产生影响。其中VEGF联系众多信号通路,对血管新生整个过程进行调节,发挥了无可替代的作用。近年来国内外对VEGF及相关信号通路调节血管新生机制的研究取得了一定的进展,对多种疾病发病机制的阐明及临床药物的研发提供了新的理论依据。我们总结了近年来相关研究成果,希望为血管新生相关疾病的治疗提供新的可能性。

引用

页码：81 / 86

页数：6

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