阿尔茨海默氏病新易感基因的研究

被引：3

作者：

黄旭程 ^{[1
]}

王莹 ^{[1
]}

黄智慧 ^{[2
]}

机构：

[1] 温州医科大学检验医学院

[2] 温州医科大学基础医学院

来源：

温州医科大学学报 | 2015年 / 03期

关键词：

阿尔茨海默氏病; 新易感基因; 外显子测序; 全基因组测序; 全基因组关联研究;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100204 [神经病学];

摘要：

在阿尔茨海默氏病(AD)新易感基因领域研究中,经典的基于连锁基因和候选基因的关联研究已经逐渐被外显子测序、全基因组测序(针对孟德尔型AD)和全基因组关联研究(针对非孟德尔型AD)等替代。通过新技术寻找到的新易感基因有助于研究潜在的疾病机制。除了大样本检测新风险因素外,新一代测序方法可以对很小数量的患者进行检测。今后的研究重点将更注重转化医学的研究、单个患者的测序和个体患者生物材料的收集,这些将成为遗传子研究的核心单位。当然这一转变需要遗传科学家和临床神经科医师的紧密合作。本文对AD遗传学的最新发现和应用进行综述。

引用

页码：225 / 231+235 +235

页数：8

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