硝化应激在酒精性肝病中的作用

被引：5

作者：

林琳

周俊英

机构：

[1] 河北医科大学第三医院感染科

来源：

国际内科学杂志 | 2009年 / 36卷 / 05期

关键词：

硝化应激; 酒精性肝病; 诱导型一氧化氮合酶; 过氧化亚硝酸根离子;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

在酒精性肝病发病过程中存在诱导型一氧化氮合酶的表达增强,生成大量一氧化氮,在氧化应激的状态下与活性氧反应生成过氧化亚硝酸根离子,从而引发硝化应激,通过介导蛋白质、核酸等的硝化,影响细胞信号转导通路,最终影响细胞的代谢等功能及细胞凋亡,参与酒精性肝病的发病。本文旨在阐述硝化应激在酒精性肝病发病机制中可能发挥的作用。

引用

页码：264 / 267

页数：4

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