急性脑梗死患者90d预后的相关因素分析

被引：11

作者：

徐晓琳

吴岑

冯娟

机构：

[1] 中国医科大学附属盛京医院神经内科

来源：

卒中与神经疾病 | 2015年 / 22卷 / 01期

关键词：

脑梗死; 碱性磷酸酶; 预后;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的探讨急性脑梗死90 d预后相关的影响因素及急性期碱性磷酸酶（ALP）水平是否为急性脑梗死预后的独立危险因子。方法收集2013年9月2014年2月于中国医科大学附属盛京医院神经内科住院治疗的急性脑梗死患者210例,全面收集与预后有关的临床资料并进行NIHSS量表评分,并于90 d后行短期预后随访,进行mRS量表评分;将mRS评分>2分定义为预后不良组,≤2分定义为预后良好组,对2组所收集资料进行统计分析。结果 210例患者进入研究队列,90 d后失访11例,失访率为5.24%,最终进入研究队列的患者为199例,其中47例（23.62%）发生预后不良事件。入院时NIHSS评分（P=0.001）、心房颤动病史（P=0.003）、碱性磷酸酶（P=0.001）、尿酸（P=0.027）以及超敏C反应蛋白（P=0.001）为急性脑梗塞90 d预后的影响因素。入院时NIHSS评分（P=0.001,OR=1.46,95%CI=1.24～1.71）、碱性磷酸酶（P=0.001,OR=1.13,95%CI=1.09～1.18）为脑梗死预后的独立危险因子。结论入院时NIHSS评分、心房颤动病史、碱性磷酸酶、尿酸以及超敏C反应蛋白为急性脑梗塞90天预后的影响因素;NIHSS评分和急性期碱性磷酸酶水平为脑梗死患者90 d预后的独立危险因子。

引用

页码：21 / 24

页数：4

共 9 条

[1] Serum Alkaline Phosphatase and Phosphate in Cerebral Atherosclerosis and Functional Outcomes After Cerebral Infarction [J].

Kim, Jinkwon ;

Song, Tae-Jin ;

Song, Dongbeom ;

Lee, Hye Sun ;

Nam, Chung Mo ;

Nam, Hyo Suk ;

Kim, Young Dae ;

Heo, Ji Hoe .

STROKE, 2013, 44 (12) :3547-3549

[2]

Predictors of Stroke Recurrence in Patients with Recent Lacunar Stroke and Response to Interventions According to Risk Status: Secondary Prevention of Small Subcortical Strokes Trial[J] . Robert G. Hart,Lesly A. Pearce,Majid F. Bakheet,Oscar R. Benavente,Robin A. Conwit,Leslie A. McClure,Robert L. Talbert,David C. Anderson.Journal of Stroke and Cerebrovascular Diseases . 2013

[3]

Decreased Uric Acid Levels Correlate with Poor Outcomes in Acute Ischemic Stroke Patients, but Not in Cerebral Hemorrhage Patients[J] . Hongliang Wu,Qian Jia,Gaifen Liu,Liping Liu,Yuehua Pu,Xingquan Zhao,Chunxue Wang,Yilong Wang,Yongjun Wang.Journal of Stroke and Cerebrovascular Diseases . 2013

[4]

The type of atrial fibrillation is associated with long‐term outcome in patients with acute ischemic stroke[J] . G. Ntaios,A. Vemmou,E. Koroboki,P. Savvari,K. Makaritsis,M. Saliaris,G. Andrikopoulos,K. Vemmos.International Journal of Cardiology . 2012

[5] High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese [J].

Huang, Yue ;

Jing, Jing ;

Zhao, Xing-Quan ;

Wang, Chun-Xue ;

Wang, Yi-Long ;

Liu, Gai-Fen ;

Wang, Chun-Juan ;

Liu, Li-Ping ;

Yang, Xiao-Meng ;

Jiao, Yan ;

Jiao, Yun ;

Wang, Li-Shi ;

Wang, Yong-Jun ;

Gu, Wei-Kuan .

CNS NEUROSCIENCE & THERAPEUTICS, 2012, 18 (03) :261-266

[6]

Phosphate: The new cholesterol? The role of the phosphate axis in non-uremic vascular disease[J] . Timothy J. Ellam,Timothy J.A. Chico.Atherosclerosis . 2011 (2)

[7] Increased serum alkaline phosphatase as a predictor of long-term mortality after stroke [J].

Ryu, W. -S. ;

Lee, S. -H. ;

Kim, C. K. ;

Kim, B. J. ;

Yoon, B. -W. .

NEUROLOGY, 2010, 75 (22) :1995-2002

[8]

Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality[J] . Marcello Tonelli,Gary Curhan,Marc Pfeffer,Frank Sacks,Ravi Thadhani,Michal L. Melamed,Natasha Wiebe,Paul Muntner.Circulation . 2009 (18)

[9] Relation between serum phosphate level and cardiovascular event rate in people with coronary disease [J].

Tonelli, M ;

Sacks, F ;

Pfeffer, M ;

Gao, ZW ;

Curhan, G .

CIRCULATION, 2005, 112 (17) :2627-2633

← 1 →