D二聚体临床应用的进展

被引：55

作者：

王兆钺

机构：

[1] 苏州大学附属第一医院,江苏省血液研究所,卫生部血栓与止血重点实验室

来源：

血栓与止血学 | 2014年 / 20卷 / 01期

关键词：

D二聚体; 静脉血栓栓塞; 弥漫性血管内凝血; 诊断;

D O I：

暂无

中图分类号：

R446.1 [生物化学检验、临床检验];

学科分类号：

100208 [临床检验诊断学];

摘要：

<正>在止血与血栓过程中,凝血酶水解血浆纤维蛋白原形成纤维蛋白单体,后者联接为纤维蛋白;同时凝血酶活化因子,使纤维蛋白交联;最后在纤溶酶的作用下,纤维蛋白降解成各种纤维蛋白降解产物(FDP),其中最小的片段为D二聚体,分子量约62 ku,在体内半衰期约3 h,主要经肾脏排泄与网状内皮系统破坏。D二聚体是纤维蛋白原在凝血酶的生成,因子的活化与纤溶酶共同作用的产物,是反映血栓形成与溶栓活性最

引用

页码：46 / 48

页数：3

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