氯通道阻断剂对KCl、5-HT引起的兔脑椎基底动脉血管环收缩效应的影响

被引：6

作者：

丁岩

关永源

熊大志

贺华

不详

机构：

[1] 中山大学医学院药理学教研室

[2] 中山大学医学院药理学教研室广州

[3] 广州

来源：

中国药理学通报 | 2002年 / 03期

基金：

广东省自然科学基金;

关键词：

脑基底动脉; Ca2+通道; Cl-通道阻断剂; KCl; 5-HT;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　探讨不同种类氯通道阻断剂在不同激动剂引起的脑血管平滑肌收缩反应中的作用。方法　记录离体兔脑椎基底动脉环收缩反应。结果　①氯通道阻断剂DIDS、Furosemide及NPPB均浓度依赖性抑制高K+ 及 5 HT引起血管环收缩反应 ,DIDS、Furosemide及NPPB对 5 HT引起收缩的抑制作用明显强于对KCl的作用 ;②在 5 HT引起血管收缩反应中 ,给予SK&F96 36 5引起血管最大舒张的基础上 ,DIDS、Furosemide及NPPB均可引起血管进一步舒张。结论　氯通道可能参与了由高K+ 去极化和 5 HT引起的兔脑椎基底动脉环收缩反应

引用

页码：267 / 271

页数：5

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