嗅鞘细胞促使脊髓挫裂伤后神经再生和功能恢复的研究

被引：26

作者：

黄红云

刘凯

黄文成

刘宗惠

Wise Young

机构：

[1] 海军总医院神经外科

[2] Rutgers大学神经科学中心

来源：

海军总医院学报 | 2001年 / 02期

关键词：

嗅鞘细胞; 脊髓挫裂伤; 神经再生; 功能恢复;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

摘要：

目的 :研究嗅鞘细胞在脊髓挫裂损伤后不同时期植入能否帮助轴突再生、穿过瘢痕和神经功能恢复。方法 :用 NYU打击器制造 Log Evans Hooded大鼠的脊髓挫裂损伤模型 ,在伤后即刻和二周后植入嗅鞘细胞 ,采用 BBB方法做行为学观察三个月 ,经运动皮层注入神经示踪剂 (BDA)后行组织化学研究。结果 :部分大鼠嗅鞘细胞植入后比对照组的神经功能恢复好 ,组织学发现这些神经功能恢复好 (BBB分数 >10 )的大鼠 ,再生神经轴突能穿过损伤瘢痕区到达损伤下段。结论 :嗅鞘细胞在脊髓挫裂损伤后即刻和二周后植入均能帮助轴突再生、穿过瘢痕和神经功能恢复。

引用

页码：65 / 67

页数：3

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