胃底贲门癌根治术中保留脾脏对预后的影响

被引:5
作者
张常华 [1 ]
何裕隆 [1 ]
詹文华 [1 ]
宋武 [1 ]
陈创奇 [1 ]
蔡世荣 [1 ]
黄美近 [2 ]
机构
[1] 中山大学附属第一医院胃肠胰外科中山大学胃癌诊治中心
[2] 中山大学附属第六医院胃肠外科
基金
广东省自然科学基金;
关键词
贲门肿瘤; 保留脾脏; 淋巴结切除术; 预后;
D O I
暂无
中图分类号
R735 [消化系肿瘤];
学科分类号
100112 [医学生物化学与分子生物学];
摘要
目的探讨胃底贲门癌根治术中保留脾脏对预后的影响。方法回顾性分析1994年7月至2003年12月间108例经根治性手术治疗的胃底贲门癌患者的临床病理资料,比较保脾与切脾两组患者的并发症发生情况和预后。结果切脾组38例,保脾组70例,最后随访日期2004年12月。本组淋巴结转移率68.5%(74/108),第10组淋巴结转移率16.7%。切脾组与保脾组术后并发症发生率(18.4%vs14%,χ2=0.318,P=0.573)、肿瘤复发率和肿瘤病理特征差异均无统计学意义。保脾组5年生存率明显高于切脾组(38.7%vs16.9%,P=0.008)。多因素分析显示,保留脾脏不是影响预后的独立因素(P=0.085),只有肿瘤浸润程度(P=0.009)和淋巴结转移(P=0.001)是独立的预后因素。结论除脾脏受侵犯者外,贲门癌根治术中应尽可能保留脾脏。
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