雌激素影响绝经后骨质疏松分子机制研究进展

被引：69

作者：

孙伟明 ^{[1
]}

刘爽 ^{[2
]}

机构：

[1] 天津中医药大学

[2] 天津中医药大学第二附属医院

来源：

中国老年学杂志 | 2017年 / 37卷 / 02期

关键词：

雌激素; 绝经后骨质疏松; 破骨细胞; 成骨细胞;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

<正>骨质疏松是以骨量减少、骨的微观结构退化为特征的,致使骨的脆性增加以及易于发生骨折的一种全身性骨骼疾病,可分为三大类即原发性骨质疏松、继发性骨质疏松、特发性骨质疏松。绝经后骨质疏松(PMOP)为Ⅰ型原发性骨质疏松,由绝经后机体雌激素水平下降而引发,年龄通常界定在50～70岁。雌激素的缺乏被认为是PMOP的主要原因,其中具体的分子机制仍未达成共识,本文结合近些年研究雌激素对PMOP发病机

引用

页码：499 / 502

页数：4

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