脑梗死患者尿酸、氧化应激水平与早期病情进展关系及普罗布考干预作用研究

被引：10

作者：

卢丹丹

王佩

万莉

李轩

魏书艳

张唯

李迎

柴美静

机构：

[1] 保定市第一中心医院神经内三科

来源：

临床军医杂志 | 2017年 / 45卷 / 01期

关键词：

尿酸; 脑梗死; 氧化应激; 普罗布考;

D O I：

10.16680/j.1671-3826.2017.01.16

中图分类号：

R743.33 [脑栓塞];

学科分类号：

摘要：

目的探讨脑梗死患者早期病情进展与氧化应激、尿酸水平的相关性及普罗布考的干预作用。方法选择2015年6月至2016年5月保定市第一中心医院收治的160例缺血性脑卒中患者为研究对象。将160例患者随机分为研究组和对照组,每组各80例。研究组患者给予阿托伐他汀钙片联合普罗布考治疗,对照组给予阿托伐他汀治疗。于发病第1天测定两组患者的超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、丙二醛(MDA)等氧化应激指标及尿酸水平,于治疗第1、3、7天应用美国国立卫生研究院脑卒中量表评分评价患者卒中进展情况。结果治疗第1天,两组患者的卒中进展概率比较,差异无统计学意义(P>0.05);治疗第3、7天,研究组卒中进展概率明显低于对照组,差异有统计学意义(P<0.05)。治疗第7天,研究组患者MDA水平较对照组低,而TAC及SOD水平较对照组高,组间比较,差异均有统计学意义(P<0.05)。尿酸与SOD、TAC水平呈正相关,与MDA水平呈负相关;且病情进展患者基线尿酸水平偏低。结论普罗布考可以通过降低脑梗死患者的氧化应激水平降低疾病早期病情进展;较高尿酸水平可降低脑梗死患者早期病情进展概率。

引用

页码：56 / 59

页数：4

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