藜欢解郁胶囊的抗抑郁作用

被引：15

作者：

刘梅 ^{[1
]}

周海松 ^{[2
,3
]}

许锦文 ^{[2
]}

李萍 ^{[3
]}

奉建芳 ^{[2
]}

机构：

[1] 上海中医药大学中药产学研合作中心

[2] 上海中医药大学穆拉德中药现代化研究中心

[3] 广西中医药大学药学院药理教研室

来源：

中成药 | 2016年 / 06期

关键词：

藜欢解郁胶囊; 抗抑郁; 单胺类神经递质; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的探讨藜欢解郁胶囊(蒺藜、合欢花、石菖蒲、甘草)抗抑郁的作用及其相关机制。方法运用慢性应激性刺激加孤养法造成大鼠抑郁模型,观察大鼠体质量、皮毛、饮食、排泄、强迫游泳不动时间和悬尾不动时间;用酶联免疫吸附法(ELISA法)观察藜欢解郁胶囊对大鼠血清去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)及皮质酮(CORT)含有量的影响;用蛋白质印迹法观察藜欢解郁胶囊对大鼠脑内海马体脑源性神经营养因子(BDNF)蛋白表达水平的影响。结果与空白组比较,模型组动物造模后体质量增长缓慢(P<0.01),动物皮毛出现干枯、斑秃、不思饮食、不喜活动等情况。与模型组比较,各给药组动物体质量增加明显(P<0.05),饮食、皮毛等较正常。藜欢解郁胶囊低、高剂量组能明显缩短大鼠的强迫游泳不动时间和悬尾不动时间(P<0.05或P<0.01),升高抑郁大鼠血清中NE、DA、5-HT的含有量及脑内海马BDNF蛋白的表达水平(P<0.05或P<0.01),降低血清中CORT的含有量(P<0.01)。结论藜欢解郁胶囊有抗抑郁作用,其作用机制可能是通过提高单胺类神经递质功能,抑制下丘脑-垂体-肾上腺轴功能,提高脑内海马BDNF的表达水平,升高5-HT含有量,保护5-HT能神经元功能等途径发挥抗抑郁作用。

引用

页码：1383 / 1387

页数：5

共 10 条

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中成药, 2014, 36 (05) :1104-1105

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